Literature associating TLR7 and Aicardi-Goutieres syndrome
Toll-like receptor 7; Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).
Synonyms: TLR7, TLR7p, hTLR7, B2R9N9, Q9NYK1 ...