DISEASES

Disease-gene associations mined from literature

Literature associating BPHL and Zika fever

BPHL [ENSP00000369739]

Biphenyl hydrolase-like (serine hydrolase); Serine hydrolase that catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir. Activates valacyclovir to acyclovir. May play a role in detoxification processes. It is a specific alpha-amino acid ester hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol; Belongs to the AB hydrolase superfamily. Lipase family.

Synonyms:  BPHL,  A0A024QZY0,  B4DML3,  F2Z2Q1,  Q49AI2 ...

Linkouts:  STRING  Pharos  UniProt  OMIM