Disease-gene associations mined from literature

Literature associating MTAP and malignant mesothelioma

MTAP [ENSP00000369519]

S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.

Synonyms:  MTAP,  B4DUC8,  F8WES2,  J3KRN1,  J3QSB7 ...

Linkouts:  STRING  Pharos  UniProt  OMIM