DISEASES

Disease-gene associations mined from literature

Literature associating IL1RAPL1 and syndromic X-linked intellectual disability

IL1RAPL1 [ENSP00000368278]

Three immunoglobulin domain-containing IL-1 receptor-related 2; May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in neurite outgrowth (By similarity). During dendritic spine formation can bidirectionally induce pre- and post-synaptic differentiation of neurons by trans- synaptically binding to PTPRD (By similarity); Belongs to the interleukin-1 receptor family.

Synonyms:  IL1RAPL1,  Q7Z2H0,  Q9NZN1,  X5DNQ7,  OPHN4 ...

Linkouts:  STRING  Pharos  UniProt