DISEASES

Disease-gene associations mined from literature

Literature associating BMP2 and bone cancer

BMP2 [ENSP00000368104]

Bone morphogenetic protein 2A; Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4; Belongs to the TGF-beta family.

Synonyms:  BMP2,  BMP2p,  hBMP2,  C8C060,  C8C069 ...

Linkouts:  STRING  Pharos  UniProt  OMIM