DISEASES

Disease-gene associations mined from literature

Literature associating NDP and exudative vitreoretinopathy

NDP [ENSP00000367301]

X-linked exudative vitreoretinopathy 2 protein; Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction; Endogenous ligands

Synonyms:  NDP,  Q00604,  EVR2,  Q00604p,  hQ00604 ...

Linkouts:  STRING  Pharos  UniProt  OMIM