DISEASES

Disease-gene associations mined from literature

Literature associating KDM6A and adhesions of uterus

KDM6A [ENSP00000367203]

Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein; Histone demethylase that specifically demethylates 'Lys- 27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A. Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression (By similarity); Lysine demethylases

Synonyms:  KDM6A,  KDM6Ap,  hKDM6A,  DKFZP686A03225,  F5H6S1 ...

Linkouts:  STRING  Pharos  UniProt  OMIM