DISEASES

Disease-gene associations mined from literature

Literature associating RECK and bone squamous cell carcinoma

RECK [ENSP00000367202]

Reversion-inducing cysteine-rich protein with Kazal motifs; Negatively regulates matrix metalloproteinase-9 (MMP-9) by suppressing MMP-9 secretion and by direct inhibition of its enzymatic activity. RECK down-regulation by oncogenic signals may facilitate tumor invasion and metastasis. Appears to also regulate MMP-2 and MT1-MMP, which are involved in cancer progression.

Synonyms:  RECK,  O95980,  O95980p,  hO95980,  ST15 ...

Linkouts:  STRING  Pharos  UniProt  OMIM