Disease-gene associations mined from literature

Literature associating SHB and sulfhemoglobinemia

SHB [ENSP00000366936]

Src homology 2 domain containing adaptor protein B; Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic- FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells; SH2 domain containing

Synonyms:  SHB,  Q15464,  SHB-001,  Q15464p,  hQ15464 ...

Linkouts:  STRING  Pharos  UniProt  OMIM