DISEASES

Disease-gene associations mined from literature

Literature associating PPP1R10 and familial melanoma

PPP1R10 [ENSP00000365694]

Serine/threonine-protein phosphatase 1 regulatory subunit 10; Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers (By similarity).

Synonyms:  PPP1R10,  PPP1R10p,  hPPP1R10,  CAT53,  FB19 ...

Linkouts:  STRING  Pharos