DISEASES

Disease-gene associations mined from literature

Literature associating TLE1 and spindle cell liposarcoma

TLE1 [ENSP00000365682]

Transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila); Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG; Belongs to the WD repeat Groucho/TLE family.

Synonyms:  TLE1,  TLE1p,  hTLE1,  Q04724,  Q5T3G2 ...

Linkouts:  STRING  Pharos  UniProt  OMIM