DISEASES

Disease-gene associations mined from literature

Literature associating TNFRSF1B and necrobiosis lipoidica

TNFRSF1B [ENSP00000365435]

Tumor necrosis factor receptor superfamily, member 1B; Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity; CD molecules

Synonyms:  TNFRSF1B,  B5A977,  P20333,  Q6LBF2,  Q9UIG9 ...

Linkouts:  STRING  Pharos  UniProt  OMIM