DISEASES

Disease-gene associations mined from literature

Literature associating ID1 and fibrodysplasia ossificans progressiva

ID1 [ENSP00000365280]

Inhibitor of DNA binding 1, dominant negative helix-loop-helix protein; Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity).

Synonyms:  ID1,  ID1p,  hID1,  P41134,  BHLHB24 ...

Linkouts:  STRING  Pharos  UniProt  OMIM