DISEASES

Disease-gene associations mined from literature

Literature associating DLG2 and bilateral retinoblastoma

DLG2 [ENSP00000365272]

Channel-associated protein of synapse-110; Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity); Membrane associated guanylate kinases

Synonyms:  DLG2,  DLG2p,  hDLG2,  A8MUT9,  A8MVA8 ...

Linkouts:  STRING  Pharos  UniProt  OMIM