DISEASES

Disease-gene associations mined from literature

Literature associating ZCCHC6 and renal Wilms' tumor

ZCCHC6 [ENSP00000365130]

Zinc finger CCHC domain-containing protein 6; Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay. Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets. Also acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7). Uridylated pre-let-7 RNA is not processed by Dicer and undergo degradation. Pre-let-7 uridylation is strongly enhanced in the presence of LIN28A. Due to functional redundancy between ZCCHC6 and ZCCHC11, the identification of the specific role of each of these proteins is difficult; Non-canonical poly(A) polymerases

Synonyms:  ZCCHC6,  ZCCHC6p,  hZCCHC6,  Q5VYS8,  Q5VYS9 ...

Linkouts:  STRING  Pharos  UniProt