Disease-gene associations mined from literature

Literature associating C6orf25 and pancytopenia

C6orf25 [ENSP00000364964]

Megakaryocyte and platelet inhibitory receptor G6b; Inhibitory receptor that acts as a critical regulator of hematopoietic lineage differentiation, megakaryocyte function and platelet production. Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide. This regulation of megakaryocate function as well as platelet production ann activation is done through the inhibition (via the 2 ITIM motifs) of the receptors CLEC1B and GP6:FcRgamma signaling. Appears to operate in a calcium-independent manner.

Synonyms:  C6orf25,  C6orf25p,  hC6orf25,  B7ZLJ5,  C6ORF25 ...

Linkouts:  STRING  Pharos