DISEASES

Disease-gene associations mined from literature

Literature associating CDC14B and adrenal gland pheochromocytoma

CDC14B [ENSP00000364389]

Dual specificity protein phosphatase CDC14B; Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint: following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome (APC/C). Dephosphorylates SIRT2 around early anaphase. Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by proline-directed kinases; Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.

Synonyms:  CDC14B,  CDC14Bp,  hCDC14B,  CDC14B-001,  CDC14B-002 ...

Linkouts:  STRING  Pharos  UniProt  OMIM