Literature associating CDC14B and adrenal gland pheochromocytoma
Dual specificity protein phosphatase CDC14B; Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint: following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome (APC/C). Dephosphorylates SIRT2 around early anaphase. Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by proline-directed kinases; Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.
Synonyms: CDC14B, CDC14Bp, hCDC14B, CDC14B-001, CDC14B-002 ...