DISEASES

Disease-gene associations mined from literature

Literature associating NOTCH4 and verrucous carcinoma

NOTCH4 [ENSP00000364163]

Neurogenic locus notch homolog protein 4; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May regulate branching morphogenesis in the developing vascular system (By similarity); Ankyrin repeat domain containing

Synonyms:  NOTCH4,  NOTCH4p,  hNOTCH4,  INT3,  4855 ...

Linkouts:  STRING  Pharos  OMIM