Literature associating LAS1L and Werdnig-Hoffmann disease
Ribosomal biogenesis protein LAS1L; Involved in the biogenesis of the 60S ribosomal subunit. Required for maturation of the 28S rRNA. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.
Synonyms: LAS1L, LAS1Lp, hLAS1L, B3KNR6, B3KUJ7 ...