DISEASES

Disease-gene associations mined from literature

Literature associating HTR1D and migraine with aura

HTR1D [ENSP00000363748]

5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction.

Synonyms:  HTR1D,  HTR1Dp,  hHTR1D,  P28221,  HTR1DA ...

Linkouts:  STRING  Pharos  UniProt