DISEASES

Disease-gene associations mined from literature

Literature associating TXN and malignant mesothelioma

TXN [ENSP00000363641]

Surface-associated sulphydryl protein; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity.

Synonyms:  TXN,  H9ZYJ2,  P10599,  H9ZYJ2p,  hH9ZYJ2 ...

Linkouts:  STRING  Pharos  UniProt  OMIM