DISEASES

Disease-gene associations mined from literature

Literature associating DKK1 and tooth agenesis

DKK1 [ENSP00000363081]

Dickkopf WNT signaling pathway inhibitor 1; Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti- apoptotic activity (By similarity); Belongs to the dickkopf family.

Synonyms:  DKK1,  DKK1p,  hDKK1,  DKK1-001,  DKK1-002 ...

Linkouts:  STRING  Pharos  UniProt  OMIM