Disease-gene associations mined from literature

Literature associating SRSF3 and ocular hypertension

SRSF3 [ENSP00000362820]

Splicing factor, arginine/serine-rich 3; Splicing factor that specifically promotes exon- inclusion during alternative splicing. Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing. Also functions as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. RNA-binding is semi-sequence specific.

Synonyms:  SRSF3,  SRSF3p,  hSRSF3,  B2R6F3,  B4E241 ...

Linkouts:  STRING  Pharos  UniProt  OMIM