DISEASES

Disease-gene associations mined from literature

Literature associating H2AFY2 and anus benign neoplasm

H2AFY2 [ENSP00000362352]

H2A histone family, member Y2; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation.

Synonyms:  H2AFY2,  H2AFY2p,  hH2AFY2,  A0A024QZP6,  H2AFY2-001 ...

Linkouts:  STRING  Pharos  UniProt