Literature associating NEURL2 and COL4A1-related familial vascular leukoencephalopathy
Neuralized E3 ubiquitin protein ligase 2; Plays an important role in the process of myofiber differentiation and maturation. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of proteins. Probably contributes to catalysis through recognition and positioning of the substrate and the ubiquitin-conjugating enzyme. During myogenesis, controls the ubiquitination and degradation of the specific pool of CTNNB1/beta-catenin located at the sarcolemma (By similarity).
Synonyms: NEURL2, NEURL2p, hNEURL2, Q9BR09, C20orf163 ...