Disease-gene associations mined from literature

Literature associating BMPR1A and lung combined large cell neuroendocrine carcinoma

BMPR1A [ENSP00000361107]

Bone morphogenetic protein receptor type-1A; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6. ; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

Synonyms:  BMPR1A,  BMPR1Ap,  hBMPR1A,  A0A087X0P8,  P36894 ...

Linkouts:  STRING  Pharos  UniProt