DISEASES

Disease-gene associations mined from literature

Literature associating NCOA3 and estrogen-receptor positive breast cancer

NCOA3 [ENSP00000361066]

Thyroid hormone receptor activator molecule 1; Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit.

Synonyms:  NCOA3,  NCOA3p,  hNCOA3,  B4DYT5,  Q0IIN7 ...

Linkouts:  STRING  Pharos  UniProt  OMIM