DISEASES

Disease-gene associations mined from literature

Literature associating PTGDS and bacterial meningitis

PTGDS [ENSP00000360687]

Lipocalin-type prostaglandin-D synthase; Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system; Lipocalins

Synonyms:  PTGDS,  A0A024R8G3,  F8W7I2,  P41222,  PTGDS-001 ...

Linkouts:  STRING  Pharos  UniProt  OMIM