DISEASES

Disease-gene associations mined from literature

Literature associating FFAR4 and obesity

FFAR4 [ENSP00000360538]

G-protein coupled receptor GT01; Receptor for medium and long-chain free fatty acids (FFAs). Signals via a G(q)/G(11)-coupled pathway. Acts as a receptor for omega-3 fatty acids and mediates robust anti- inflammatory effects, particularly in macrophages and fat cells. The anti-inflammatory effects involve inhibition of TAK1 through a beta-arrestin 2 (ARRB2)/TAB1-dependent effect, but independent of the G(q)/G(11)-coupled pathway. Mediates potent insulin sensitizing and antidiabetic effects by repressing macrophage- induced tissue inflammation. May mediate the taste of fatty acids. Mediates FFA-induced inhibition of apoptosis in enteroendocrine cells. May play a role in the regulation of adipocyte development and differentiation.

Synonyms:  FFAR4,  FFAR4p,  hFFAR4,  Q5NUL3,  S4R3L2 ...

Linkouts:  STRING  Pharos  UniProt