Disease-gene associations mined from literature

Literature associating PTGFR and ocular hypertension

PTGFR [ENSP00000359793]

Prostaglandin F2-alpha receptor; Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum (By similarity). Isoforms 2 to 7 do not bind PGF2-alpha but are proposed to modulate signaling by participating in variant receptor complexes; heterodimers between isoform 1 and isoform 5 are proposed to be a receptor for prostamides including the synthetic analog bimatoprost.

Synonyms:  PTGFR,  F2Z2Z6,  P43088,  F2Z2Z6p,  hF2Z2Z6 ...

Linkouts:  STRING  Pharos  UniProt  OMIM