DISEASES

Disease-gene associations mined from literature

Literature associating GOT1 and hepatic coma

GOT1 [ENSP00000359539]

Glutamic-oxaloacetic transaminase 1, soluble; Biosynthesis of L-glutamate from L-aspartate or L- cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3- mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

Synonyms:  GOT1,  GOT1p,  hGOT1,  P17174,  P17174p ...

Linkouts:  STRING  Pharos  UniProt  OMIM