DISEASES

Disease-gene associations mined from literature

Literature associating DR1 and vulvitis

DR1 [ENSP00000359295]

Down-regulator of transcription 1, TBP-binding (negative cofactor 2); The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.

Synonyms:  DR1,  DR1p,  hDR1,  DKFZP666G145,  Q01658 ...

Linkouts:  STRING  Pharos  UniProt