DISEASES

Disease-gene associations mined from literature

Literature associating DBT and primary biliary cholangitis

DBT [ENSP00000359151]

Branched-chain alpha-keto acid dehydrogenase complex component E2; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). Within this complex, the catalytic function of this enzyme is to accept, and to transfer to coenzyme A, acyl groups that are generated by the branched-chain alpha-keto acid decarboxylase component.

Synonyms:  DBT,  P11182,  Q5VVL7,  BCATE2,  P11182p ...

Linkouts:  STRING  Pharos  UniProt  OMIM