DISEASES

Disease-gene associations mined from literature

Literature associating HTR1B and alcohol use disorder

HTR1B [ENSP00000358963]

5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries.

Synonyms:  HTR1B,  HTR1Bp,  hHTR1B,  P28222,  X5D7I5 ...

Linkouts:  STRING  Pharos  UniProt  OMIM