DISEASES

Disease-gene associations mined from literature

Literature associating TTK and chronic polyneuropathy

TTK [ENSP00000358813]

Phosphotyrosine picked threonine-protein kinase; Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.

Synonyms:  TTK,  D6REX1,  D6RF82,  D6RFY1,  D6RIC6 ...

Linkouts:  STRING  Pharos  UniProt  OMIM