DISEASES

Disease-gene associations mined from literature

Literature associating CD101 and histiocytosis

CD101 [ENSP00000358482]

Glu-Trp-Ile EWI motif-containing protein 101; Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activated T-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and cellular proliferation. Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3- induced changes in intracellular free calcium. Prevents nuclear translocation of nuclear factor of activated T-cell to the nucleus. Plays a role in the inhibition of T-cell proliferation via IL10 secretion by cutaneous dendritic cells. May be a marker of CD4(+) CD56(+) leukemic tumor cells.

Synonyms:  CD101,  CD101p,  hCD101,  Q93033,  EWI101 ...

Linkouts:  STRING  Pharos  UniProt