Literature associating TCF7L2 and Wolfram syndrome
Transcription factor 7-like 2 (T-cell specific, HMG-box); Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine; TCF/LEF transcription factor family
Synonyms: TCF7L2, TCF7L2p, hTCF7L2, B3KQC6, B4E165 ...