DISEASES

Disease-gene associations mined from literature

Literature associating HIST2H2AA and parasitic protozoa infectious disease

HIST2H2AA [ENSP00000358155]

Histone cluster 2, H2aa4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Synonyms:  HIST2H2AA4,  HIST2H2AA3,  Q6FI13,  H2AFO,  HIST2H2AA ...

Linkouts:  STRING  Pharos  UniProt