Disease-gene associations mined from literature

Literature associating HIST2H3C and Wolf-Hirschhorn syndrome

HIST2H3C [ENSP00000358154]

Histone cluster 2, H3c; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Synonyms:  HIST2H3C,  126961,  2IIJ,  2X4W,  2X4X ...

Linkouts:  STRING  Pharos