DISEASES

Disease-gene associations mined from literature

Literature associating HIST2H2BE and amyotrophic lateral sclerosis type 6

HIST2H2BE [ENSP00000358151]

Histone cluster 2, H2be; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Synonyms:  HIST2H2BE,  Q16778,  Q8N257,  H2BFQ,  HIST3H2BB ...

Linkouts:  STRING  Pharos  UniProt #1 #2  OMIM