Disease-gene associations mined from literature

Literature associating EIF3A and brachydactyly type E1

EIF3A [ENSP00000358140]

Eukaryotic translation initiation factor 3 subunit 10; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression; Armadillo-like helical domain containing

Synonyms:  EIF3A,  EIF3Ap,  hEIF3A,  EIF3A-001,  EIF3A-002 ...

Linkouts:  STRING  Pharos  UniProt  OMIM