DISEASES

Disease-gene associations mined from literature

Literature associating MKI67 and breast disease

MKI67 [ENSP00000357643]

Antigen identified by monoclonal antibody Ki-67; Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly. Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface. Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility. Binds DNA, with a preference for supercoiled DNA and AT-rich DNA. Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization. It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable); Protein phosphatase 1 regulatory subunits

Synonyms:  MKI67,  MKI67p,  hMKI67,  P46013,  P46013p ...

Linkouts:  STRING  Pharos  UniProt  OMIM