DISEASES

Disease-gene associations mined from literature

Literature associating TPM3 and nemaline myopathy

TPM3 [ENSP00000357516]

Tropomyosin alpha-3 chain; Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments; Belongs to the tropomyosin family.

Synonyms:  TPM3,  TPM3p,  hTPM3,  B4DWT5,  D6R904 ...

Linkouts:  STRING  Pharos  UniProt  OMIM