Disease-gene associations mined from literature

Literature associating ROS1 and lung combined large cell neuroendocrine carcinoma

ROS1 [ENSP00000357494]

ROS proto-oncogene 1 , receptor tyrosine kinase; Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2; Fibronectin type III domain containing

Synonyms:  ROS1,  ROS1p,  hROS1,  H0Y3T9,  P08922 ...

Linkouts:  STRING  Pharos  UniProt  OMIM