DISEASES

Disease-gene associations mined from literature

Literature associating GOPC and neurogenic bowel

GOPC [ENSP00000357484]

Golgi-associated PDZ and coiled-coil motif-containing protein; Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes; PDZ domain containing

Synonyms:  GOPC,  GOPC-001,  GOPC-002,  GOPC-003,  GOPC-201 ...

Linkouts:  STRING  Pharos  UniProt  OMIM