DISEASES

Disease-gene associations mined from literature

Literature associating NUS1 and adhesions of uterus

NUS1 [ENSP00000357480]

Nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae); With DHDDS, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Adds multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER). Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol. Acts as a specific receptor for the N-terminus of Nogo-B, a neural and cardiovascular regulator.

Synonyms:  NUS1,  NUS1p,  hNUS1,  Q96E22,  C6orf68 ...

Linkouts:  STRING  Pharos  UniProt  OMIM