DISEASES

Disease-gene associations mined from literature

Literature associating FCRL3 and Graves' disease

FCRL3 [ENSP00000357167]

Immune receptor translocation-associated protein 3; Promotes TLR9-induced B-cell proliferation, activation and survival but inhibits antibody production and suppresses plasma cell differentiation. Enhances activation of NF-kappa-B and MAPK signaling pathways in TLR9 stimulated B-cells. Has inhibitory potentional on B-cell receptor (BCR)-mediated signaling, possibly through association with SH2 domain-containing phosphatases. Inhibits cell tyrosine phosphorylation, calcium mobilization and activation-induced cell death induced through BCR signaling. Regulatory T-cells expressing FCRL3 exhibit a memory phenotype, are relatively nonresponsive to antigenic stimulation in presence of IL2 and have reduced capacity to suppress the proliferation of effector T-cells; CD molecules

Synonyms:  FCRL3,  FCRL3p,  hFCRL3,  Q96P31,  R4GNJ6 ...

Linkouts:  STRING  Pharos  UniProt  OMIM