DISEASES

Disease-gene associations mined from literature

Literature associating F11R and MEDNIK syndrome

F11R [ENSP00000357005]

Junctional adhesion molecule 1; Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6- PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier (By similarity). Ligand for integrin alpha- L/beta-2 involved in memory T-cell and neutrophil transmigration. Involved in platelet activation; Belongs to the immunoglobulin superfamily.

Synonyms:  F11R,  F11Rp,  hF11R,  B7Z941,  Q6FIB4 ...

Linkouts:  STRING  Pharos  UniProt