DISEASES

Disease-gene associations mined from literature

Literature associating DEDD and ideomotor apraxia

DEDD [ENSP00000356985]

Death effector domain-containing testicular molecule; A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. Inhibits DNA transcription in vitro (By similarity); Death effector domain containing

Synonyms:  DEDD,  B1AQP5,  O75618,  V9GY27,  B1AQP5p ...

Linkouts:  STRING  Pharos  UniProt  OMIM