DISEASES

Disease-gene associations mined from literature

Literature associating ADAMTS4 and thoracic aortic aneurysm

ADAMTS4 [ENSP00000356975]

A disintegrin and metalloproteinase with thrombospondin motifs 4; Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-|-Ala-393' site; ADAM metallopeptidases with thrombospondin type 1 motif

Synonyms:  ADAMTS4,  ADAMTS4p,  hADAMTS4,  O75173,  Q5VTW1 ...

Linkouts:  STRING  Pharos  UniProt  OMIM